November 27, 2024
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How does the endocrine system work with the digestive system?

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The gastrointestinal endocrine system

Gastrointestinal endocrinology is the study of the hormonal regulation of digestion. A number of characterized polypeptide hormones have been localized in specific gastroenteropancreatic endocrine cells. The fact that some of these hormones are also found in nerve and brain cells has given rise to the concept of a gut-brain axis. The functional capacities of these endocrine cells are determined by their anatomic location; the luminal exposure of gastroenteric endocrine cells represents an additional avenue for stimulation and release that is not open to pancreatic endocrine cells. Gastroenteropancreatic hormones regulate carbohydrate metabolism, gastric acid secretion, pancreatic exocrine and gallbladder function, gastrointestinal motility and blood flow. These important regulatory hormones may in turn be controlled by a series of gastroduodenal releasing hormones.

Diabetes mellitus is the most important metabolic disorder related to a gastroenteropancreatic hormone imbalance. Most tumours producing these hormones are of pancreatic origin and produce a number of hormones; insulinomas and gastrinomas are detected readily because of the serious metabolic distrubances they cause. Other instances of altered circulating concentrations of these hormones result from rather than cause the disease.

The challenge of future study is to determine if postprandial changes in the plasma concentrations of these hormones are sufficient or necessary, or both, for the control of digestion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  • Track NS. Evolutionary aspects of the gastrointestinal hormones. Comp Biochem Physiol B. 1973 Jun 15; 45 (2):291–301. [PubMed] [Google Scholar]
  • Melani F. Pro-hormones in tissues and in circulation. Horm Metab Res. 1974 Jan; 6 (1):1–8. [PubMed] [Google Scholar]
  • Dockray GJ. Comparative biochemistry and physiology of gut hormones. Annu Rev Physiol. 1979; 41 :83–95. [PubMed] [Google Scholar]
  • Straus E. Radioimmunoassay of gastrointestinal hormones. Gastroenterology. 1978 Jan; 74 (1):141–152. [PubMed] [Google Scholar]
  • Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS. Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer. Gut. 1976 Oct; 17 (10):745–754. [PMC free article] [PubMed] [Google Scholar]
  • Uvnäs-Wallensten K, Rehfeld JF, Larsson LI, Uvnäs B. Heptadecapeptide gastrin in the vagal nerve. Proc Natl Acad Sci U S A. 1977 Dec; 74 (12):5707–5710. [PMC free article] [PubMed] [Google Scholar]
  • Rehfeld JF. Localisation of gastrins to neuro- and adenohypophysis. Nature. 1978 Feb 23; 271 (5647):771–773. [PubMed] [Google Scholar]
  • Muller JE, Straus E, Yalow RS. Cholecystokinin and its COOH-terminal octapeptide in the pig brain. Proc Natl Acad Sci U S A. 1977 Jul; 74 (7):3035–3037. [PMC free article] [PubMed] [Google Scholar]
  • Martino E, Lernmark A, Seo H, Steiner DF, Refetoff S. High concentration of thyrotropin-releasing hormone in pancreatic islets. Proc Natl Acad Sci U S A. 1978 Sep; 75 (9):4265–4267. [PMC free article] [PubMed] [Google Scholar]
  • Larsson L-I Corticotropin-like peptides in central nerves and in endocrine cells of gut and pancreas. Lancet. 1977 Dec 24; 2 (8052-8053):1321–1323. [PubMed] [Google Scholar]
  • Pearse AG. The diffuse neuroendocrine system and the apud concept: related “endocrine” peptides in brain, intestine, pituitary, placenta, and anuran cutaneous glands. Med Biol. 1977 Jun; 55 (3):115–125. [PubMed] [Google Scholar]
  • Pictet RL, Rall LB, Phelps P, Rutter WJ. The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells. Science. 1976 Jan 16; 191 (4223):191–192. [PubMed] [Google Scholar]
  • Fontaine J, Le Douarin NM. Analysis of endoderm formation in the avian blastoderm by the use of quail-chick chimaeras. The problem of the neurectodermal origin of the cells of the APUD series. J Embryol Exp Morphol. 1977 Oct; 41 :209–222. [PubMed] [Google Scholar]
  • Fiddian-Green RG, Farrell J, Havlichek D, Jr, Kothary P, Pittenger G. A physiological role for luminal gastrin? Surgery. 1978 Jun; 83 (6):663–668. [PubMed] [Google Scholar]
  • Matsuyama T, Foà PP. Plasma glucose, insulin, pancreatic, and enteroglucagon levels in normal and depancreatized dogs. Proc Soc Exp Biol Med. 1974 Oct; 147 (1):97–102. [PubMed] [Google Scholar]
  • McDonald TJ, Nilsson G, Vagne M, Ghatei M, Bloom SR, Mutt V. A gastrin releasing peptide from the porcine nonantral gastric tissue. Gut. 1978 Sep; 19 (9):767–774. [PMC free article] [PubMed] [Google Scholar]
  • Morley JE, Levin SR, Pehlevanian M, Adachi R, Pekary AE, Hershman JM. The effects of thyrotropin-releasing hormone on the endocrine pancreas. Endocrinology. 1979 Jan; 104 (1):137–139. [PubMed] [Google Scholar]
  • Creutzfeldt M. Candidate hormones of the gut. XV. Insulin-releasing factors of the gastrointestinal mucosa (Incretin). Gastroenterology. 1974 Oct; 67 (4):748–750. [PubMed] [Google Scholar]
  • Walsh JH, Grossman MI. Gastrin (first of two parts). N Engl J Med. 1975 Jun 19; 292 (25):1324–1334. [PubMed] [Google Scholar]
  • Rayford PL, Miller TA, Thompson JC. Secretin, cholecystokinin and newer gastrointestinal hormones (first of two parts). N Engl J Med. 1976 May 13; 294 (20):1093–1101. [PubMed] [Google Scholar]
  • Adelson JW, Rothman SS. Candidate hormones of the gut. II. Chymodenin. Gastroenterology. 1974 Oct; 67 (4):731–733. [PubMed] [Google Scholar]
  • Greenberg GR, McCloy RF, Adrian TE, Chadwick VS, Baron JH, Bloom SR. Inhibition of pancreas and gallbladder by pancreatic polypeptide. Lancet. 1978 Dec 16; 2 (8103):1280–1282. [PubMed] [Google Scholar]
  • Carr-Locke DL, Track NS. Human pancreatic polypeptide in pancreatic juice. Lancet. 1979 Jan 20; 1 (8108):151–152. [PubMed] [Google Scholar]
  • Domschke W. Motilin: spectrum and mode of gastrointestinal actions. Am J Dig Dis. 1977 May; 22 (5):454–491. [PubMed] [Google Scholar]
  • Bryant MG, Polak MM, Modlin I, Bloom SR, Albuquerque RH, Pearse AG. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet. 1976 May 8; 1 (7967):991–993. [PubMed] [Google Scholar]
  • Turkington RW, Weindling HK. Insulin secretion in the diagnosis of adult-onset diabetes mellitus. JAMA. 1978 Sep 1; 240 (9):833–836. [PubMed] [Google Scholar]
  • Goulder TJ, Alberti KG. Dietary fibre and diabetes. Diabetologia. 1978 Oct; 15 (4):285–287. [PubMed] [Google Scholar]
  • Creutzfeldt W. Pancreatic endocrine tumors–the riddle or their origin and hormone secretion. Isr J Med Sci. 1975 Jul; 11 (7):762–776. [PubMed] [Google Scholar]
  • Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS. Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol. 1975 Jan; 6 (1):47–76. [PubMed] [Google Scholar]
  • Said SI, Faloona GR. Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic, bronchogenic and other tumors. N Engl J Med. 1975 Jul 24; 293 (4):155–160. [PubMed] [Google Scholar]
  • Welbourn RB. Apudomas of the gut. Am J Surg. 1977 Jan; 133 (1):13–22. [PubMed] [Google Scholar]
  • Creutzfeldt W, Arnold R, Creutzfeldt C, Deuticke U, Frerichs H, Track NS. Biochemical and morphological investigations of 30 human insulinomas. Correlation between the tumour content of insulin and proinsulin-like components and the histological and ultrastructural appearance. Diabetologia. 1973 Jun; 9 (3):217–231. [PubMed] [Google Scholar]
  • Krejs GJ, Walsh JH, Morawski SG, Fordtran JS. Intractable diarrhea. Intestinal perfusion studies and plasma VIP concentrations in patients with pancreatic cholera syndrome and surreptitious ingestion of laxatives and diuretics. Am J Dig Dis. 1977 Apr; 22 (4):280–292. [PubMed] [Google Scholar]
  • Barbezat GO, Grossman MI. Cholera-like diarrhoea induced by glucagon plus gastrin. Lancet. 1971 May 15; 1 (7707):1025–1026. [PubMed] [Google Scholar]
  • Sanzenbacher LJ, Mekhjian HS, King DR, Zollinger RM. Studies on the potential role of secretin in the islet cell tumor diarrheogenic syndrome. Ann Surg. 1972 Sep; 176 (3):394–402. [PMC free article] [PubMed] [Google Scholar]
  • Elias E, Polak JM, Bloom SR, Pearse AG, Welbourn RB, Booth CC, Kuzio M, Brown JC. Pancreatic cholera due to production of gastric inhibitory polypeptide. Lancet. 1972 Oct 14; 2 (7781):791–793. [PubMed] [Google Scholar]
  • Larsson LI, Schwartz T, Lundqvist G, Chance RE, Sundler F, Rehfeld JF, Grimelius L, Fahrenkrug J, Schaffalitzky de Muckadell O, Moon N. Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors. Possible implication in the watery diarrhea syndrome. Am J Pathol. 1976 Dec; 85 (3):675–684. [PMC free article] [PubMed] [Google Scholar]
  • Hällgren R, Karlsson FA, Lundqvist G. Serum level of immunoreactive gastrin: influence of kidney function. Gut. 1978 Mar; 19 (3):207–213. [PMC free article] [PubMed] [Google Scholar]
  • Bilbrey GL, Faloona GR, White MG, Atkins C, Hull AR, Knochel JP. Hyperglucagonemia in uremia: reversal by renal transplantation. Ann Intern Med. 1975 Apr; 82 (4):525–528. [PubMed] [Google Scholar]
  • O’Dorisio TM, Sirinek KR, Mazzaferri EL, Cataland S. Renal effects on serum gastric inhibitory polypeptide (GIP). Metabolism. 1977 Jun; 26 (6):651–656. [PubMed] [Google Scholar]
  • Hällgren R, Lundqvist G, Chance RE. Serum levels of human pancreatic polypeptide in renal disease. Scand J Gastroenterol. 1977; 12 (8):923–927. [PubMed] [Google Scholar]
  • McLeod RS, Track NS, Reynolds LE. Elevated plasma motilin concentrations in chronic renal disease. Can Med Assoc J. 1979 Aug 4; 121 (3):268–273. [PMC free article] [PubMed] [Google Scholar]
  • Besterman HS, Bloom SR, Sarson DL, Blackburn AM, Johnston DI, Patel HR, Stewart JS, Modigliani R, Guerin S, Mallinson CN. Gut-hormone profile in coeliac disease. Lancet. 1978 Apr 15; 1 (8068):785–788. [PubMed] [Google Scholar]

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